MTHFR Test
Understand your MTHFR gene variants at home. Cheek-swab DNA test for C677T and A1298C, related to methylation, in a NATA-accredited Australian lab.
Product details: AUD 139 — InStock — SKU 50185018BUCCAL — GetTested
About this test – MTHFR Test
Why test for MTHFR variants?
Genetic variations in the MTHFR gene can influence how certain biochemical processes function in the body, particularly those related to methylation.
This test may be relevant when exploring:
Interest in genetic factors related to methylation
Elevated homocysteine levels
Family history of MTHFR variants
A deeper understanding of individual genetic traits
How it works
Collect a cheek swab sample at home
Send your sample to the laboratory using the prepaid return envelope
Your sample is analysed using validated laboratory methods
Receive your digital results within 7 days
Key information
Sample type: Buccal swab (cheek swab)
Turnaround time: 7 days from when the lab receives your sample
Results: Delivered digitally
Laboratory: Accredited laboratory
Shipping: Return shipping included
Accredited Laboratory
Your sample is analysed at a NATA-accredited laboratory in Australia, operating in accordance with ISO 15189 standards for medical testing. This ensures that all analyses are performed using validated methods and strict quality control procedures to provide accurate and reliable results.
Biomarkers included – MTHFR Test
- MTHFR C677T genetic variant: MTHFR C677T is a genetic variant in the MTHFR gene, which helps the body convert folate into a form used for methylation. Methylation is involved in normal DNA production, cell function, nervous system activity and the recycling of homocysteine, a substance formed during protein metabolism. The C677T variant can reduce the efficiency of the MTHFR enzyme, especially when two copies are present. Thi
- MTHFR A1298C genetic variant: MTHFR A1298C is a genetic variant in the MTHFR gene, which is involved in folate metabolism and methylation. Through this pathway, folate helps support normal cell function, nervous system activity and homocysteine regulation. A1298C is generally considered less strongly linked to homocysteine changes than C677T on its own, but it may still influence MTHFR enzyme function. It can be especially rel
How to prepare – MTHFR Test
No fasting is required. Ensure your mouth is clean by rinsing with water 30 minutes before testing. Avoid eating, drinking, smoking, or chewing gum for 30 minutes prior to collecting the swab sample.
Frequently asked questions – MTHFR Test
What is the difference between C677T and A1298C?
C677T is primarily associated with the conversion of homocysteine and heart health, while A1298C is more closely linked to neurotransmitter balance and mood stability. Carrying variants in both (known as compound heterozygous) can significantly impact overall methylation efficiency more than a single variant alone.
Do I need to stop taking supplements before the test?
No. Because this is a genetic DNA test, your results will not change based on recent food or supplement intake. Unlike a blood test that measures current circulating folate levels, your DNA remains constant throughout your life.
What do 'Homozygous' and 'Heterozygous' mean?
Homozygous means you inherited the same variant from both parents (two copies), which typically results in a more significant reduction in enzyme activity. Heterozygous means you inherited the variant from only one parent (one copy), usually resulting in a milder impact on enzyme function.
Customer reviews – MTHFR Test
4.6/5 (5)
- 5/5 — The swab process was quick and I got my results exactly on the 7th day. Glad I finally know my status.
- 4/5 — Clear instructions provided. It took a little longer than a week for the email to arrive, but the report was helpful.
- 5/5 — Helpful test for my health.
- 5/5 — Fast delivery and very easy to use at home.
- 4/5 — Good kit. Results are easy to read.